Poly(ethylene glycol)s With a Single Cinnamaldehyde Acetal Unit for Fabricating Acid-Degradable Hydrogel

Frontiers in Chemistry

Haiwei Liu¹  Zhongyu Li¹  Zhihui Li²  Peihan Cai³  Pengfei Shan³  Xinyue Zhao³  Daai Li⁴ 

[1] Vision Science, School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, China;College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, China;;State Key Laboratory of Optometry &The Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;

关键词: poly(ethylene glycol);    hydrogel;    cinnamaldehyde;    acetal;    acid-degradable;   

DOI  :  10.3389/fchem.2020.00839

来源: DOAJ

【 摘 要 】

A synthetic route to prepare a poly(ethylene glycol) with a single cinnamaldehyde acetal unit in the polymer chain, was successfully established using a newly synthesized cinnamaldehyde acetal diethylene glycol (CADEG) as initiator. This HO-PEG(ca)-OH is non-toxic and would be degraded into a cinnamaldehyde and two PEG diols in acid environment. A whole polyethylene glycol based hydrogel was easily fabricated by thiol-ene “click” reaction in alkalescence aqueous solution using acrylate-PEG(ca)-acrylate and 4-arm PEG-SH as raw materials at room temperature. The gel time was dependent on the pH of the solution and its alkalinity can promote gel. The hydrogel can be degradable in acidic conditions and the stronger the acidity, the faster the degradation. This HO-PEG(ca)-OH also can be used in synthesis of cinnamaldehyde containing PEG derivatives, block copolymers or other acid degradable materials.

【 授权许可】

Unknown