An Efficient Greener Approach for N-Acylation of Amines in Water Using Benzotriazole Chemistry

Molecules

SivaS. Panda¹  HaniZ. Asfour²  TarekS. Ibrahim³  Mohamed Elagawany⁴  AmanyM. M. Al-Mahmoudy⁵  IsraaA. Seliem⁵  ZakariaK. M. Abdel-Samii⁵  NabilA. Alhakamy⁶ 

[1] Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA;Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;Department of Pharmaceutical Chemistry, faculty of pharmacy, Damanhour University, Damanhour 22511, Egypt;Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt;Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;

关键词: green chemistry;    one-pot synthesis;    acylation;    benzotriazole chemistry;    benzimidazole;    microwave;   

DOI  :  10.3390/molecules25112501

来源: DOAJ

【 摘 要 】

A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the key advantages of this protocol.

【 授权许可】

Unknown