Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases

International Journal of Molecular Sciences

MariaCristina Barbalace¹  Marco Malaguti¹  Silvana Hrelia¹  Antonio Lucacchini²  Laura Giusti³  Cristina Angeloni³ 

[1] Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy;Department of Clinical and Experimental Medicine, University of Pisa, Pisa 56126, Italy;School of Pharmacy, University of Camerino, 62032 Camerino, Italy;

关键词: neuroinflammation;    neurodegeneration;    algae;    seaweeds;    neurodegenerative diseases;   

DOI  :  10.3390/ijms20123061

来源: DOAJ

【 摘 要 】

Neuroinflammation is one of the main contributors to the onset and progression of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. Microglial and astrocyte activation is a brain defense mechanism to counteract harmful pathogens and damaged tissues, while their prolonged activation induces neuroinflammation that can trigger or exacerbate neurodegeneration. Unfortunately, to date there are no pharmacological therapies able to slow down or stop the progression of neurodegeneration. For this reason, research is turning to the identification of natural compounds with protective action against these diseases. Considering the important role of neuroinflammation in the onset and development of neurodegenerative pathologies, natural compounds with anti-inflammatory activity could be good candidates for developing effective therapeutic strategies. Marine organisms represent a huge source of natural compounds, and among them, algae are appreciated sources of important bioactive components such as antioxidants, proteins, vitamins, minerals, soluble dietary fibers, polyunsaturated fatty acids, polysaccharides, sterols, carotenoids, tocopherols, terpenes, phycobilins, phycocolloids, and phycocyanins. Recently, numerous anti-inflammatory compounds have been isolated from marine algae with potential protective efficacy against neuroinflammation. This review highlights the key inflammatory processes involved in neurodegeneration and the potential of specific compounds from marine algae to counteract neuroinflammation in the CNS.

【 授权许可】

Unknown