Experiences in the treatment of refractory chylothorax associated with lymphoproliferative disorders

Orphanet Journal of Rare Diseases

Monika Motyckova¹  Pavel Zak¹  David Belada¹  Pavla Stepankova¹  Jana Pospiskova¹  Alice Sykorova¹  Martin Simkovic¹  Lukas Smolej¹ 

[1] 4th Department of Internal Medicine – Hematology, University Hospital;

关键词: Chylothorax;    Non-Hodgkin′s lymphoma;    Chronic lymphocytic leukemia;    Radiotherapy;    Thoracic duct;   

DOI  :  10.1186/s13023-018-0991-3

来源: DOAJ

【 摘 要 】

Abstract Background Chylothorax is a rare condition which can be associated with malignant lymphoproliferative disorders (LPDs). We retrospectively analyzed the results of the conservative treatment of 10 patients with persistent non-traumatic malignant chylothorax. Results Conservative treatment lead to a decline of chylothorax after mean of 66 days and consisted of the treatment of the underlying disease and of simultaneous long-term supportive care (drainage of the thoracic cavity, dietary measures and nutrition management). In most cases (80%), chylothorax disappeared only after a successful therapeutic response of the underlying disease. Low-dose radiotherapy had very good effects in two patients. Conclusion Conservative treatment of malignant chylothorax can be considered a suitable method. Based on our results, successful treatment of the lymphoproliferative disorder seems to be a very important factor for the disappearance of chylothorax.

【 授权许可】

Unknown