The role of collagen in cancer: from bench to bedside

Journal of Translational Medicine

Hao Li¹  Shuaishuai Xu¹  Xianjun Yu¹  Wenquan Wang¹  Huaxiang Xu¹  Tianjiao Li¹  Wuhu Zhang¹  Shuo Li¹  Liang Liu¹ 

[1] Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center;

关键词: Collagen;    Cancer;    Mutated genes;    Signaling pathways;    Tumor microenvironment;    Prognosis;   

DOI  :  10.1186/s12967-019-2058-1

来源: DOAJ

【 摘 要 】

Abstract Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling pathways and receptors; furthermore, collagen can influence tumor cell behavior through integrins, discoidin domain receptors, tyrosine kinase receptors, and some signaling pathways. Exosomes and microRNAs are closely associated with collagen in cancer. Hypoxia, which is common in collagen-rich conditions, intensifies cancer progression, and other substances in the extracellular matrix, such as fibronectin, hyaluronic acid, laminin, and matrix metalloproteinases, interact with collagen to influence cancer cell activity. Macrophages, lymphocytes, and fibroblasts play a role with collagen in cancer immunity and progression. Microscopic changes in collagen content within cancer cells and matrix cells and in other molecules ultimately contribute to the mutual feedback loop that influences prognosis, recurrence, and resistance in cancer. Nanoparticles, nanoplatforms, and nanoenzymes exhibit the expected gratifying properties. The pathophysiological functions of collagen in diverse cancers illustrate the dual roles of collagen and provide promising therapeutic options that can be readily translated from bench to bedside. The emerging understanding of the structural properties and functions of collagen in cancer will guide the development of new strategies for anticancer therapy.

【 授权许可】

Unknown