Dimer targeting peptide mediated precise and controllable drug delivery by upconversion nanocarriers for breast cancer therapy

Materials & Design

Yongsheng Yu¹  Zhong Wan²  Yanchun Meng³  Xiufeng Xiao⁴  Kunyu Zhang⁴  Huabo Jiang⁵  Qian Feng⁶ 

[1] Corresponding authors.;Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA;Bioengineering College, Chongqing University, Chongqing 400030, China;Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China;Department of Urology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China;Fujian Province Key Laboratory of Advanced Materials Oriented Chemical Engineering, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian 350007, China;

关键词: Near-infrared light control;    Upconversion nanoparticle;    Epirubicin;    targeting peptide;    Breast cancer;   

DOI  :  

来源: DOAJ

【 摘 要 】

Breast cancer is one of the leading causes of cancer-related deaths in women. Chemotherapy remains one of the main clinical treatments for breast cancer. However, this therapy has appreciable side effects. Nanoscale carriers, such as metal nanoparticles and liposomes, are being widely utilized as drug delivery vehicles to achieve precise targeting of tumor cells. In this study, we designed a novel upconversion nanocarriers (UCNCs) host-guest complexation system based on a photolabile capping-like molecule. UCNCs containing epirubicin (EPI) were grafted with a dimer-targeting peptide via cyclodextrin-adamantine host-guest complexation. After entering breast tumor cells with the guidance of the dimer-targeting peptide, the core of the UCNCs upconverted near-infrared light to ultraviolet light which subsequently triggered the intracellular on-demand release of epirubicin. The precise and efficient delivery and release of epirubicin inside breast cancer cells significantly inhibited cancer cells proliferation, migration, and invasion in vitro and decreased the tumor size in vivo. We believe that this UCNCs system is a promising platform for the precise and controllable delivery of various chemotherapy drugs for clinical cancer treatments.

【 授权许可】

Unknown