EWS–FLI1‐targeting peptide identifies Ewing sarcoma tumor boundaries and lymph node metastasis via near‐infrared imaging

Molecular Oncology

Hairen Chen¹  Xiang Hu¹  Yu Wang¹  Ying Yuan¹  Aixi Yu¹  Song Wu²  Hengtang Mai² 

[1] Department of Orthopaedic Trauma and Microsurgery Wuhan University Zhongnan Hospital China;Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals School of Pharmaceutical Sciences Wuhan University China;

关键词: Ewing sarcoma;    EWS–FLI1;    near‐infrared imaging;    surgical guidance;    targeting peptide;   

DOI  :  10.1002/1878-0261.13081

来源: DOAJ

【 摘 要 】

Ewing sarcoma (ES) is one of the most aggressive types of pediatric tumors. The lack of tools for the identification of ES has largely hindered clinical diagnosis and the improvement of treatment. To address this challenge, we synthesized a near‐infrared (NIR) fluorescent probe (CS2‐N‐E9R) that targets the ES‐specific fusion protein EWS–FLI1 (E/F). This probe exhibited specific and high binding affinity to E/F. Further studies in animal models showed that CS2‐N‐E9R can be used to identify the boundaries of ES and lymph node metastases under a complex biological environment. These results demonstrate that CS2‐N‐E9R is a promising probe for early diagnosis and surgical guidance of ES through molecularly targeted NIR imaging.

【 授权许可】

Unknown