Adipose Tissue Fibrosis: Mechanisms, Models, and Importance

International Journal of Molecular Sciences

RosalynD. Abbott¹  MeganK. DeBari² 

[1] Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA;Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA;

关键词: adipose tissue;    fibrosis;    in vitro models;    in vivo models;    biomaterials;   

DOI  :  10.3390/ijms21176030

来源: DOAJ

【 摘 要 】

Increases in adipocyte volume and tissue mass due to obesity can result in inflammation, further dysregulation in adipose tissue function, and eventually adipose tissue fibrosis. Like other fibrotic diseases, adipose tissue fibrosis is the accumulation and increased production of extracellular matrix (ECM) proteins. Adipose tissue fibrosis has been linked to decreased insulin sensitivity, poor bariatric surgery outcomes, and difficulty in weight loss. With the rising rates of obesity, it is important to create accurate models for adipose tissue fibrosis to gain mechanistic insights and develop targeted treatments. This article discusses recent research in modeling adipose tissue fibrosis using in vivo and in vitro (2D and 3D) methods with considerations for biomaterial selections. Additionally, this article outlines the importance of adipose tissue in treating other fibrotic diseases and methods used to detect and characterize adipose tissue fibrosis.

【 授权许可】

Unknown