Scores of Health-Related Quality of Life Questionnaire Worsen Consistently in Patients of COPD: Estimating Disease Progression Over 30 Years by SReFT with Individual Data Collected in SUMMIT Trial

Journal of Clinical Medicine

Akihiro Hisaka¹  Shinya Kawamatsu¹  Ryota Jin¹  Hiromi Sato¹  Shogo Araki¹  Hideki Yoshioka¹  Yasunori Sato² 

[1] Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675, Japan;Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo 160-8582, Japan;

关键词: chronic obstructive pulmonary disease;    disease progression;    health-related quality of life;    smoking;    statistical restoration of fragmented time-course;   

DOI  :  10.3390/jcm9082676

来源: DOAJ

【 摘 要 】

The aim of this study was to elucidate the lifelong disease progression of chronic obstructive pulmonary disease (COPD) with biomarker changes and identify their influencing factors, by utilizing a new analysis method, Statistical Restoration of Fragmented Time-course (SReFT). Individual patient data (n = 1025) participating in the Study to Understand Mortality and MorbidITy (SUMMIT, NCT01313676), which was collected within the observational period of 4 years, were analyzed. The SReFT analysis suggested that scores of St. George’s Respiratory Questionnaire and COPD assessment test, representative scores of the health-related quality of life (HRQOL) questionnaire, increased consistently for 30 years of disease progression, which was not detected by conventional analysis with a linear mixed effect model. It was estimated by the SReFT analysis that normalized forced expiratory volume in one second for age, sex, and body size (%FEV1) reduced for the initial 10 years from the onset of the disease but thereafter remained constant. The analysis of HRQOL scores and lung functions suggested that smoking cessation slowed COPD progression by approximately half and that exacerbation accelerated it considerably. In conclusion, this retrospective study utilizing SReFT elucidated the progression of COPD over 30 years and associated quantitative changes in the HRQOL scores and lung functions.

【 授权许可】

Unknown