Serendipitous Stimulation of Nucleus Basalis of Meynert—The Effect of Unintentional, Long-Term High-Frequency Stimulation on Cognition in Parkinson’s Disease

Journal of Clinical Medicine

on behalf of the NSTAPS Study Group¹  Vincent J. Odekerken²  Rob M. A. de Bie²  Judith A. Boel²  Teus van Laar³  Rients B. Huitema³  I. Daria Bogdan⁴  D. L. Marinus Oterdoom⁴  J. Marc C. van Dijk⁴ 

[1] ;Department of Neurology, Amsterdam Neuroscience Institute, Amsterdam University Medical Center, 1105 Amsterdam, The Netherlands;Department of Neurology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands;Department of Neurosurgery, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands;

关键词: Parkinson’s disease;    Parkinson’s disease dementia;    cognitive impairments;    cognitive function;    deep brain stimulation;   

DOI  :  10.3390/jcm11020337

来源: DOAJ

【 摘 要 】

There is a growing interest in deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) as a potential therapeutic modality for Parkinson’s disease dementia (PDD). Low-frequency stimulation has yielded encouraging results in individual patients; however, these are not yet sustained in larger studies. With the aim to expand the understanding of NBM-DBS, we share our experience with serendipitous NBM-DBS in patients treated with DBS of the internal Globus pallidus (GPi) for Parkinson’s disease. Since NBM is anatomically located ventral to GPi, several GPi-treated patients appeared to have the distal contact of DBS-electrode(s) positioned in the NBM. We hypothesized that unintentional high-frequency NBM-DBS over a period of one year would result in the opposite effect of low-frequency NBM-stimulation and cause cognitive decline. We studied a cohort of 33 patients with bilateral high-frequency DBS in the GPi for Parkinson’s disease, of which twelve were unintentionally co-stimulated in NBM. The subgroups of unintentional unilateral (N = 7) and bilateral NBM-DBS (N = 5) were compared to the control group of bilateral GPi-DBS (N = 11). Here, we show that unintentional high-frequency NBM-DBS did not cause a significantly faster decline in cognitive function. Further research is warranted for characterizing the therapeutic role of NBM-DBS.

【 授权许可】

Unknown