Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells

International Journal of Molecular Sciences

NatalyaV. Pashintseva¹  SergeyS. Shishkin¹  LeonidI. Kovalev¹  MarinaA. Kovaleva¹  Ksenia Lisitskaya¹ 

[1] Laboratory of Biomedical Research, Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt, 33, bld. 2, 119071 Moscow, Russia;

关键词: heterogeneous nuclear ribonucleoproteins;    telomere;    telomerase;    human malignant cells;   

DOI  :  10.3390/ijms20030745

来源: DOAJ

【 摘 要 】

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are structurally and functionally distinct proteins containing specific domains and motifs that enable the proteins to bind certain nucleotide sequences, particularly those found in human telomeres. In human malignant cells (HMCs), hnRNP-A1—the most studied hnRNP—is an abundant multifunctional protein that interacts with telomeric DNA and affects telomerase function. In addition, it is believed that other hnRNPs in HMCs may also be involved in the maintenance of telomere length. Accordingly, these proteins are considered possible participants in the processes associated with HMC immortalization. In our review, we discuss the results of studies on different hnRNPs that may be crucial to solving molecular oncological problems and relevant to further investigations of these proteins in HMCs.

【 授权许可】

Unknown