Telomerase Regulation from Beginning to the End

Genes

Chantal Autexier¹  Hélène Jeanne Bensoussan¹  Deanna Elise MacNeil¹ 

[1] Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte Ste-Catherine Road, Montréal, QC H3T 1E2, Canada;

关键词: telomerase;    telomere;    H/ACA ribonucleoprotein;    small nucleolar RNA;    small Cajal body RNA;    spliceosome;    exosome;   

DOI  :  10.3390/genes7090064

来源: DOAJ

【 摘 要 】

The vast body of literature regarding human telomere maintenance is a true testament to the importance of understanding telomere regulation in both normal and diseased states. In this review, our goal was simple: tell the telomerase story from the biogenesis of its parts to its maturity as a complex and function at its site of action, emphasizing new developments and how they contribute to the foundational knowledge of telomerase and telomere biology.

【 授权许可】

Unknown