The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner

eLife

Konrad Basler¹  Daniel Hain²  Eduardo Moreno²  Federico Germani³  Denise Sternlicht³ 

[1] Champalimaud Research Center Lisbon, Lisboa, Portugal;Institute of Cell Biology, University of Bern, Bern, Switzerland;Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland;

关键词: Toll pathway;    cell growth;    cell competition;    innate Immunity;    cell fitness;   

DOI  :  10.7554/eLife.39939

来源: DOAJ

【 摘 要 】

The Toll pathway regulates the cellular response to infection via the transcriptional upregulation of antimicrobial peptides. In Drosophila, apart from its role in innate immunity, this pathway has also been reported to be important for the elimination of loser cells in a process referred to as cell competition, which can be locally triggered by secreted factors released from winner cells. In this work, we provide evidence that the inhibition of Toll signaling not only increases the fitness of loser cells, but also bestows a clonal growth advantage on wild-type cells. We further demonstrate that this growth advantage depends on basal infection levels since it is no longer present under axenic conditions but exacerbated upon intense pathogen exposure. Thus, the Toll pathway functions as a fine-tuned pro-apoptotic and anti-proliferative regulator, underlining the existence of a trade-off between innate immunity and growth during development.

【 授权许可】

Unknown