A clash on the Toll pathway: competitive action between pesticides and zymosan A on components of innate immunity in Apis mellifera

Frontiers in Immunology

Immunology

Ali Kanso¹  Philippe Laval-Gilly²  Jairo Falla-Angel²  Dani Sukkar³ 

[1] Biology Department, Faculty of Sciences I, Lebanese University, Hadath, Lebanon;Laboratoire Sols et Environnement, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Lorraine, Nancy, France;Laboratoire Sols et Environnement, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Lorraine, Nancy, France;Biology Department, Faculty of Sciences I, Lebanese University, Hadath, Lebanon;

关键词: Toll pathway;    immune modulation;    β-glucan;    imidacloprid;    amitraz;    honeybees;    immune genes;   

DOI  :  10.3389/fimmu.2023.1247582

 received in 2023-07-21, accepted in 2023-08-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe immune system of honeybees includes multiple pathways that may be affected by pesticide exposure decreasing the immune competencies of bees and increasing their susceptibility to diseases like the fungal Nosema spp. infection, which is detected in collapsed colonies.MethodsTo better understand the effect of the co-presence of multiple pesticides that interact with bees like imidacloprid and amitraz, we evaluated the expression of immune-related genes in honeybee hemocytes.ResultsImidacloprid, amitraz, and the immune activator, zymosan A, mainly affect the gene expression in the Toll pathway.DiscussionImidacloprid, amitraz, and zymosan A have a synergistic or an antagonistic relationship on gene expression depending on the level of immune signaling. The presence of multiple risk factors like pesticides and pathogens requires the assessment of their complex interaction, which has differential effects on the innate immunity of honeybees as seen in this study.

【 授权许可】

Unknown   
Copyright © 2023 Sukkar, Kanso, Laval-Gilly and Falla-Angel