Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

International Journal of Molecular Sciences

JohnG. Hardy¹  Sofia Municoy²  MaríaI. Álvarez Echazú²  JuanM. Galdopórpora²  MartinF. Desimone²  AndreaM. Mebert²  MaríaL. Foglia²  Christian Olivetti²  MaríaV. Tuttolomondo²  GiselaS. Alvarez²  PabloE. Antezana² 

[1] Department of Chemistry, Faraday Building, Lancaster University, Lancaster, Lancashire LA1 4YB, UK;Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA), Facultad de Farmacia y Bioquímica Junín 956, Piso 3° (1113), Buenos Aires 1113, Argentina;

关键词: stimuli-responsive materials;    tissue engineering;    drug delivery;    biomaterials;    thermoresponsive;    pH-responsive;   

DOI  :  10.3390/ijms21134724

来源: DOAJ

【 摘 要 】

Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity of stimuli response, and ability to respond to endogenous cues inherently present in living systems provide possibilities to develop novel tissue engineering and drug delivery strategies (for example materials composed of stimuli responsive polymers that self-assemble or undergo phase transitions or morphology transformations). Herein, smart materials as controlled drug release vehicles for tissue engineering are described, highlighting their potential for the delivery of precise quantities of drugs at specific locations and times promoting the controlled repair or remodeling of tissues.

【 授权许可】

Unknown