Magnesium Affects Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Content andComposition by Affecting Glucose Uptake in Delftia acidovorans

Malaysian Journal of Microbiology

关键词: Polyhydroxyalkanoates;    4-hydroxybutyrate;    Delftia acidovorans;    1;    4-butanediol;    Magnesium;   

DOI  :  

来源: DOAJ

【 摘 要 】

Precise control of polyhydroxyalkanoate (PHA) composition is necessary in order to synthesize polymers with specific properties. Among the various types of PHA that have beenidentified, those that contain 4-hydroxybutyrate (4HB) monomers are especially useful in the medical and pharmaceutical fields as absorbable biomaterial. In this study, we have investigated the effect of magnesium concentration on the biosynthesis of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] byDelftia acidovorans DS-17. Our results show that, magnesium affects the copolymer content and composition by affecting glucose uptake from the culture medium. Higher concentrations of magnesium resulted in lower molar fractions of 3HB in the copolymer and reduced uptake of glucose. The results show for the first time that magnesium may be used to achieve fine control of biologically synthesized PHA copolymer composition.

【 授权许可】

Unknown