Cancer Salivary Biomarkers for Tumours Distant to the Oral Cavity

International Journal of Molecular Sciences

Blanca Majem¹  María Mercedes Suarez-Cunqueiro²  Óscar Rapado-González²  Rafa López-López³  Laura Muinelo-Romay³ 

[1] Biomedical Research Unit in Gynecology, Vall Hebron Research Institute (VHIR) and University Hospital, Autonomous University of Barcelona, Barcelona 08035, Spain;Department of Surgery and Surgical Medical Specialties, Medicine and Dentistry School, University of Santiago de Compostela, Santiago de Compostela 15782, Spain;Liquid Biopsy Analysis Unit, Health Research Institute of Santiago (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (SERGAS), Santiago de Compostela 15706, Spain;

关键词: non-invasive diagnosis;    saliva;    systemic diseases;    biomarkers;    cancer;   

DOI  :  10.3390/ijms17091531

来源: DOAJ

【 摘 要 】

The analysis of saliva as a diagnostic approach for systemic diseases was proposed just two decades ago, but recently great interest in the field has emerged because of its revolutionary potential as a liquid biopsy and its usefulness as a non-invasive sampling method. Multiple molecules isolated in saliva have been proposed as cancer biomarkers for diagnosis, prognosis, drug monitoring and pharmacogenetic studies. In this review, we focus on the current status of the salivary diagnostic biomarkers for different cancers distant to the oral cavity, noting their potential use in the clinic and their applicability in personalising cancer therapies.

【 授权许可】

Unknown