Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review

Molecules

Priscilla Porto-Figueira¹  JorgeA. M. Pereira¹  JoséS. Câmara¹  Pritam Sukul²  Ravindra Taware³  Srikanth Rapole³ 

[1] CQM - Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal;Department of Anaesthesiology and Intensive Care Medicine, Rostock Medical Breath Research Analytics and Technologies (ROMBAT), Rostock University Medical Centre, 18057 Rostock, Germany;Proteomics Lab, National Centre for Cell Science (NCCS), Ganeshkhind Road, SPPU Campus, Pune 411007, India;

关键词: saliva;    volatile organic compounds (VOCs);    oral diseases (ODs);    biomarkers;    analytical platforms;   

DOI  :  10.3390/molecules25133098

来源: DOAJ

【 摘 要 】

Fostered by the advances in the instrumental and analytical fields, in recent years the analysis of volatile organic compounds (VOCs) has emerged as a new frontier in medical diagnostics. VOCs analysis is a non-invasive, rapid and inexpensive strategy with promising potential in clinical diagnostic procedures. Since cellular metabolism is altered by diseases, the resulting metabolic effects on VOCs may serve as biomarkers for any given pathophysiologic condition. Human VOCs are released from biomatrices such as saliva, urine, skin emanations and exhaled breath and are derived from many metabolic pathways. In this review, the potential of VOCs present in saliva will be explored as a monitoring tool for several oral diseases, including gingivitis and periodontal disease, dental caries, and oral cancer. Moreover, the analytical state-of-the-art for salivary volatomics, e.g., the most common extraction techniques along with the current challenges and future perspectives will be addressed unequivocally.

【 授权许可】

Unknown