The biology, function, and applications of exosomes in cancer

Acta Pharmaceutica Sinica B

Yihui Yang¹  Liwen Ren¹  Jie Yi¹  Wan Li¹  Guanhua Du¹  Jinyi Liu²  Jinhua Wang²  Sha Li²  Weiqi Fu²  Xiangjin Zheng² 

[1] Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China;The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing 100050, China;

关键词: Exosomes;    Tumor immunity;    Tumor metastasis;    Drug resistance;    Biomarkers;    Drug delivery;   

DOI  :  

来源: DOAJ

【 摘 要 】

Exosomes are cell-derived nanovesicles with diameters from 30 to 150 nm, released upon fusion of multivesicular bodies with the cell surface. They can transport nucleic acids, proteins, and lipids for intercellular communication and activate signaling pathways in target cells. In cancers, exosomes may participate in growth and metastasis of tumors by regulating the immune response, blocking the epithelial–mesenchymal transition, and promoting angiogenesis. They are also involved in the development of resistance to chemotherapeutic drugs. Exosomes in liquid biopsies can be used as non-invasive biomarkers for early detection and diagnosis of cancers. Because of their amphipathic structure, exosomes are natural drug delivery vehicles for cancer therapy.

【 授权许可】

Unknown