Polycaprolactone-Based, Porous CaCO3 and Ag Nanoparticle Modified Scaffolds as a SERS Platform With Molecule-Specific Adsorption

Frontiers in Chemistry

Andre G. Skirtach¹  Bogdan Parakhonskiy¹  Ekaterina Prikhozhdenko²  Mariia Saveleva³  Dmitry Gorin⁴  Alexey Yashchenok⁴ 

[1] Department of Biotechnology, Ghent University, Ghent, Belgium;Department of Nano- and Biomedical Technologies, Saratov State University, Saratov, Russia;Education and Research Institute of Nanostructures and Biosystems, Saratov State University, Saratov, Russia;Skoltech Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, Moscow, Russia;

关键词: SERS;    Raman;    calcium carbonate;    silver nanoparticles;    vaterite;   

DOI  :  10.3389/fchem.2019.00888

来源: DOAJ

【 摘 要 】

Surface-enhanced Raman scattering (SERS) is a high-performance technique allowing detection of extremely low concentrations of analytes. For such applications, fibrous polymeric matrices decorated with plasmonic metal nanostructures can be used as flexible SERS substrates for analysis of analytes in many application. In this study, a three-dimensional SERS substrate consisting of a CaCO3-mineralized electrospun (ES) polycaprolactone (PCL) fibrous matrix decorated with silver (Ag) nanoparticles is developed. Such modification of the fibrous substrate allows achieving a significant increase of the SERS signal amplification. Functionalization of fibers by porous CaCO3 (vaterite) and Ag nanoparticles provides an effective approach of selective adsorption of biomolecules and their precise detection by SERS. This new SERS substrate represents a promising biosensor platform with selectivity to low and high molecular weight molecules.

【 授权许可】

Unknown