Impact of Body Mass Index on the Survival of Patients with Sepsis with Different Modified NUTRIC Scores

Nutrients

Yu-Ping Chang¹  Yi-Hsi Wang¹  Chiung-Yu Lin¹  Wen-Feng Fang¹  Yi-Hsuan Tsai¹  Hung-Cheng Chen¹  Kai-Yin Hung¹  Yung-Che Chen¹  Chin-Chou Wang¹  Kuo-Tung Huang¹  Meng-Chih Lin¹  Yu-Mu Chen¹  Ya-Chun Chang¹ 

[1] Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan;

关键词: sepsis;    nutrition;    survival;    underweight;   

DOI  :  10.3390/nu13061873

来源: DOAJ

【 摘 要 】

Nutritional status affects the survival of patients with sepsis. This retrospective study analyzed the impact of body mass index (BMI) and modified nutrition risk in critically ill (mNUTRIC) scores on survival of these patients. Data of 1291 patients with sepsis admitted to the intensive care unit (ICU) were extracted. The outcomes were mortality, duration of stay, ICU stay, and survival curve for 90-day mortality. Logistic regression analysis was performed to examine the risk factors for mortality. Cytokine and biomarker levels were analyzed in 165 patients. The 90-day survival of underweight patients with low mNUTRIC scores was significantly better than that of normal-weight patients with low mNUTRIC scores (70.8% vs. 58.3%, respectively; p = 0.048). Regression model analysis revealed that underweight patients with low mNUTRIC scores had a lower risk of mortality (odds ratio = 0.557; p = 0.082). Moreover, normal-weight patients with low mNUTRIC scores had the lowest human leukocyte antigen DR (HLA-DR) level on days 1 (underweight vs. normal weight vs. overweight: 94.3 vs. 82.1 vs. 94.3, respectively; p = 0.007) and 3 (91.8 vs. 91.0 vs. 93.2, respectively; p = 0.047). Thus, being underweight may not always be harmful if patients have optimal clinical nutritional status. Additionally, HLA-DR levels were the lowest in patients with low survival.

【 授权许可】

Unknown