Beyond PARP1: The Potential of Other Members of the Poly (ADP-Ribose) Polymerase Family in DNA Repair and Cancer Therapeutics

Frontiers in Cell and Developmental Biology

Emma Bolderson¹  Iain A. Richard¹  Joshua T. Burgess¹  Kenneth J. O’Byrne² 

[1] Cancer and Ageing Research Program (CARP), Centre for Genomics and Personalised Health (CGPH), Queensland University of Technology (QUT), Brisbane, QLD, Australia;Princess Alexandra Hospital, Brisbane, QLD, Australia;

关键词: PARP;    cancer;    DNA damage;    DNA repair;    genomic stability;    tumourigenesis;   

DOI  :  10.3389/fcell.2021.801200

来源: DOAJ

【 摘 要 】

The proteins within the Poly-ADP Ribose Polymerase (PARP) family encompass a diverse and integral set of cellular functions. PARP1 and PARP2 have been extensively studied for their roles in DNA repair and as targets for cancer therapeutics. Several PARP inhibitors (PARPi) have been approved for clinical use, however, while their efficacy is promising, tumours readily develop PARPi resistance. Many other members of the PARP protein family share catalytic domain homology with PARP1/2, however, these proteins are comparatively understudied, particularly in the context of DNA damage repair and tumourigenesis. This review explores the functions of PARP4,6-16 and discusses the current knowledge of the potential roles these proteins may play in DNA damage repair and as targets for cancer therapeutics.

【 授权许可】

Unknown