Body Fat Changes and Liver Safety in Obese and Overweight Women Supplemented with Conjugated Linoleic Acid: A 12-Week Randomised, Double-Blind, Placebo-Controlled Trial

Nutrients

Aleksandra Lisowska¹  Anna Miśkiewicz-Chotnicka²  Jarosław Walkowiak²  Ida Judyta Malesza²  Edyta Mądry³  Mehala Subramaniapillai³  Agata Czochralska-Duszyńska³  Marek Walkowiak⁴ 

[1] Department of Clinical Auxology and Pediatric Nursing, Poznan University of Medical Sciences, 61701 Poznań, Poland;Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 61701 Poznań, Poland;Department of Physiology, Poznan University of Medical Sciences, 61701 Poznań, Poland;Division of Reproduction, Department of Gynecology and Obstetrics, Poznan University of Medical Sciences, 61701 Poznań, Poland;

关键词: liver;    cytochrome P450;    ¹³C-methacetin breath test;    obesity;    adipose tissue;    body composition;   

DOI  :  10.3390/nu12061811

来源: DOAJ

【 摘 要 】

Preliminary evidence suggests that conjugated linoleic acid (CLA) may reduce body weight and affect body composition. The present study assessed the effect of CLA supplementation on body fat composition in overweight and obese women, while also evaluating the liver safety of CLA use. Seventy-four obese or overweight women were randomly assigned to receive 3 g/day CLA or placebo for 12 weeks. Body composition (dual-energy X-ray absorptiometry) and liver function (¹³C-methacetin breath test and serum liver enzymes) were assessed before and after the trial. Patients receiving CLA experienced a significant reduction of total body fat expressed as mass (p = 0.0007) and percentage (p = 0.0006), android adipose tissue (p = 0.0002), gynoid adipose tissue (p = 0.0028), and visceral adipose tissue (p = 4.2 × 10⁻⁹) as well as a significant increase in lean body mass to height (p = 6.1 × 10⁻¹¹) when compared to those receiving a placebo. The maximum momentary 13C recovery changes and end-point values were significantly higher in the CLA group when compared to the placebo group (p = 0.0385 and p = 0.0076, respectively). There were no significant changes in alanine aminotransferase, asparagine aminotransferase, and gamma-glutamyl transpeptidase activities between the groups. In conclusion, CLA supplementation was well tolerated and safe for the liver, which shows beneficial effects on fat composition in overweight and obese women.

【 授权许可】

Unknown