Advancing host-directed therapy for tuberculosis: new therapeutic insights from the Toxoplasma gondii

Microbial Cell

Chul-Su Yang¹ 

[1] Department of Molecular and Life Science, Hanyang University, Ansan 15588, S. Korea.;

关键词: Toxoplasma gondii;    GRA7;    macrophages;    protein-protein interactions;    Mycobacterium tuberculosis;   

DOI  :  10.15698/mic2017.03.565

来源: DOAJ

【 摘 要 】

Tuberculosis (TB) drug-development strategies, a wide range of candidate host-directed therapies (HDT)s-including new and repurposed drugs, biologics, and cellular therapies-have been proposed to accelerate eradication of infection and overcome the problems associated with current treatment regimens. By investigating the interaction between macrophages and the intracellular parasite Toxoplasma gondii (T. gondii), we uncovered that infection-induced signaling pathways suggest possibilities for the development of novel therapeutic modalities for TB that target the intracellular signaling pathways permitting the replication of Mycobacterium tuberculosis (MTB).

【 授权许可】

Unknown