Differential Diagnosis of Crohn’s Disease and Ulcerative Primary Intestinal Lymphoma: A Scoring Model Based on a Multicenter Study

Frontiers in Oncology

Naizhong Hu¹  Zhanju Liu²  Congling Wang³  Wei Han⁴  Huimin Zhang⁴  Bei Tan⁴  Jiaming Qian⁴  Hong Yang⁴  Tao Guo⁴  Qian Cao⁵  Yamin Lai⁶  Rui Feng⁷  Liangru Zhu⁸  Xiang Gao⁹  Wei Liu^1,10  Zhihua Ran^1,11  Kaichun Wu^1,12 

[1] Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;Shanghai Inflammatory Bowel Disease Research Center;0Department of Gastroenterology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy Medical Sciences and Peking Union Medical College, Beijing, China;Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine Zhejiang University, Hangzhou, China;Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, China;Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;Department of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China;Department of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;Department of Radiology, Peking Union Medical College Hospital, Chinese Academy Medical Sciences and Peking Union Medical College, Beijing, China;Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health;State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an, China;

关键词: Crohn’s disease;    ulcerative primary intestinal lymphoma;    diagnosis;    imaging;    scoring model;   

DOI  :  10.3389/fonc.2022.856345

来源: DOAJ

【 摘 要 】

BackgroundDifferential diagnosis of Crohn’s disease (CD) and ulcerative primary intestinal lymphoma (UPIL) is a tough problem in clinical practice.AimsOur study identified key differences between CD and UPIL patients and aimed to further establish a scoring model for differential diagnosis.MethodsA total of 91 CD and 50 UPIL patients from 9 tertiary inflammatory bowel disease centers were included. Univariate and multivariate analyses were used to determine significant markers for differentiating CD and UPIL. A differential scoring model was established by logistic regression analysis.ResultsThe differential model was based on clinical symptoms, endoscopic and imaging features that were assigned different scores: intestinal bleeding (−2 points), extraintestinal manifestation (2 points), segmental lesions (1 point), cobblestone sign (2 points), homogeneous enhancement (−1 point), mild enhancement (−1 point), engorged vasa recta (1 point). A total score of ≥1 point indicates CD, otherwise UPIL was indicated. This model produced an accuracy of 83.66% and an area under the ROC curve of 0.947. The area under the ROC curve for validation using the 10-fold validation method was 0.901.ConclusionThis study provided a convenient and useful model to differentiate CD from UPIL.

【 授权许可】

Unknown