The RhoA-ROCK pathway in the regulation of T and B cell responses [version 1; referees: 3 approved]

F1000Research

Luvana Chowdhury¹  Woelsung Yi²  Alessandra B. Pernis³  Edd Ricker⁴ 

[1] Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, New York, 10021, USA;David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York, 10021, USA;Department of Medicine, Weill Cornell Medical College, New York, New York, 10021, USA;Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, New York, 10065, USA;

关键词: Animal Genetics;    Biocatalysis;    Cell Adhesion;    Genetics of the Immune System;    Immunomodulation;    Innate Immunity;    Leukemia & Proliferative Disorders of Hematic Cells;    Leukocyte Activation;    Leukocyte Development;    Leukocyte Signaling & Gene Expression;    Lymphomas & Myelomas;    Medical Genetics;    Pediatric Hematology;    Protein Chemistry & Proteomics;   

DOI  :  10.12688/f1000research.7522.1

来源: DOAJ

【 摘 要 】

Effective immune responses require the precise regulation of dynamic interactions between hematopoietic and non-hematopoietic cells. The Rho subfamily of GTPases, which includes RhoA, is rapidly activated downstream of a diverse array of biochemical and biomechanical signals, and is emerging as an important mediator of this cross-talk. Key downstream effectors of RhoA are the Rho kinases, or ROCKs. The ROCKs are two serine-threonine kinases that can act as global coordinators of a tissue’s response to stress and injury because of their ability to regulate a wide range of biological processes. Although the RhoA-ROCK pathway has been extensively investigated in the non-hematopoietic compartment, its role in the immune system is just now becoming appreciated. In this commentary, we provide a brief overview of recent findings that highlight the contribution of this pathway to lymphocyte development and activation, and the impact that dysregulation in the activation of RhoA and/or the ROCKs may exert on a growing list of autoimmune and lymphoproliferative disorders.

【 授权许可】

Unknown