SARS-CoV-2 Seroprevalence Among Health Care Workers in Major Private and Public Hospitals With COVID-19 Patient's Referral in Tehran, Iran

Frontiers in Public Health

Melineh Markarian¹  Anahita Sadeghi¹  Reza Malekzadeh¹  Mohammad Zamani¹  Maryam Darvishian²  Payam Tabarsi³  Parvaneh Baghai³  Mona Talaschian⁴  Alireza Abdollahi⁵  Fatemeh Shafighian⁶  Masoud Mardani⁷  Hossein Poustchi⁸  Saba Alvand⁸  Zahra Mohammadi⁸  Amaneh Shayanrad⁸  Maryam Sharafkhah⁸  Sanam Hariri⁸  Farzin Roozafzai⁸  Khosro Sadeghniiat-haghighi⁹  Mohamadreza Jafary^1,10 

[1] 0Digestive Disease Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;Cancer Control Research, BC Cancer Research Centre, Vancouver, BC, Canada;Clinical Tb and Epidemiology Research Center, NRITLD, Shaheed Beheshti University of Medical Sciences, Tehran, Iran;Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;Department of Pathology, School of Medicine, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran;Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Liver and Pancreatobiliary Diseases Research Center, Shariati Hospital, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran;Occupational Sleep Research Center, Tehran University of Medical Sciences, Tehran, Iran;Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;

关键词: SARS-CoV-2;    seroprevalence;    health-care worker;    personal protective equipment;    COVID-19;   

DOI  :  10.3389/fpubh.2022.832003

来源: DOAJ

【 摘 要 】

Estimating the prevalence of SARS-CoV-2 antibody seropositivity among health care workers (HCWs) is crucial. In this study, the seroprevalence of anti-SARS-CoV-2 antibodies among HCWs of five hospitals of Tehran, Iran with high COVID-19 patient's referrals from April to June, 2020, was assessed. In this cross-sectional study, HCWs from three public and two private hospitals, selected randomly as a pilot, were included. Participants were asked questions on their demographic characteristics, medical history, hospital role, and usage of personal protective equipment (PPE). Iran FDA-approved SARS-CoV-2 ELISA kits were used to detect IgG and IgM antibodies in blood samples. The seroprevalence was estimated on the basis of ELISA test results and adjusted for test performance. Among the 2,065 participants, 1,825 (88.4%) and 240 (11.6%) HCWs were recruited from public and private hospitals, respectively. A total of 340 HCWs were tested positive for SARS-CoV-2-specific IgG or IgM antibodies, and 17.9% of seropositive individuals were asymptomatic. The overall test performance-adjusted seroprevalence estimate among HCWs was 22.6 (95% CI: 20.2–25.1), and PPE usage was significantly higher among HCWs of public vs. private hospitals (66.5 vs. 20.0%). This study found that seroprevalence of SARS-CoV-2 among HCWs was higher in private hospitals (37.0%; 95% CI: 28.6–46.2) than public hospitals (20.7%; 95% CI: 18.2–23.3), and also highest among assistant nurses and nurses, and lowest among janitor or superintendent categories. The PPE usage was especially suboptimal among HCWs in private hospitals. Continued effort in access to adequate PPE and regular screening of hospital staff for detecting asymptomatic personnel, especially during the upcoming wave of infection, are warranted.

【 授权许可】

Unknown