SARS-CoV-2 Seroprevalence Among Health Care Workers in Major Private and Public Hospitals With COVID-19 Patient's Referral in Tehran, Iran

Frontiers in Public Health

article

Maryam Darvishian¹  Maryam Sharafkhah²  Zahra Mohammadi²  Khosro Sadeghniiat-haghighi³  Alireza Abdollahi⁴  Mohamadreza Jafary⁵  Mona Talaschian⁶  Payam Tabarsi⁷  Parvaneh Baghai⁷  Masoud Mardani⁸  Amaneh Shayanrad²  Fatemeh Shafighian⁹  Melineh Markarian^1,10  Farzin Roozafzai²  Mohammad Zamani^1,10  Saba Alvand²  Sanam Hariri²  Anahita Sadeghi^1,10  Hossein Poustchi²  Reza Malekzadeh⁹ 

[1] Cancer Control Research, BC Cancer Research Centre;Liver and Pancreatobiliary Diseases Research Center, Shariati Hospital, Digestive Diseases Research Institute, Tehran University of Medical Sciences;Occupational Sleep Research Center, Tehran University of Medical Sciences;Department of Pathology, School of Medicine, Imam Hospital Complex, Tehran University of Medical Sciences;Shariati Hospital, Tehran University of Medical Sciences;Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences;Clinical Tb and Epidemiology Research Center, NRITLD, Shaheed Beheshti University of Medical Sciences;Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences;Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences;Digestive Disease Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences

关键词: SARS-CoV-2;    seroprevalence;    health-care worker;    personal protective equipment;    COVID-19;   

DOI  :  10.3389/fpubh.2022.832003

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Estimating the prevalence of SARS-CoV-2 antibody seropositivity among health care workers (HCWs) is crucial. In this study, the seroprevalence of anti-SARS-CoV-2 antibodies among HCWs of five hospitals of Tehran, Iran with high COVID-19 patient's referrals from April to June, 2020, was assessed. In this cross-sectional study, HCWs from three public and two private hospitals, selected randomly as a pilot, were included. Participants were asked questions on their demographic characteristics, medical history, hospital role, and usage of personal protective equipment (PPE). Iran FDA-approved SARS-CoV-2 ELISA kits were used to detect IgG and IgM antibodies in blood samples. The seroprevalence was estimated on the basis of ELISA test results and adjusted for test performance. Among the 2,065 participants, 1,825 (88.4%) and 240 (11.6%) HCWs were recruited from public and private hospitals, respectively. A total of 340 HCWs were tested positive for SARS-CoV-2-specific IgG or IgM antibodies, and 17.9% of seropositive individuals were asymptomatic. The overall test performance-adjusted seroprevalence estimate among HCWs was 22.6 (95% CI: 20.2–25.1), and PPE usage was significantly higher among HCWs of public vs. private hospitals (66.5 vs. 20.0%). This study found that seroprevalence of SARS-CoV-2 among HCWs was higher in private hospitals (37.0%; 95% CI: 28.6–46.2) than public hospitals (20.7%; 95% CI: 18.2–23.3), and also highest among assistant nurses and nurses, and lowest among janitor or superintendent categories. The PPE usage was especially suboptimal among HCWs in private hospitals. Continued effort in access to adequate PPE and regular screening of hospital staff for detecting asymptomatic personnel, especially during the upcoming wave of infection, are warranted.

【 授权许可】

CC BY