Potential Clinical Application of Genomics in Multiple Myeloma

International Journal of Molecular Sciences

WeeJoo Chng¹  Melissa Ooi¹  CinnieYentia Soekojo¹  Sanjay de Mel¹  Benedict Yan² 

[1] Department of Hematology-Oncology, National University Cancer Institute, Singapore, National University Health System, 1E Kent Ridge Road, Singapore 119228, Singapore;Department of Laboratory Medicine, National University Hospital, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Singapore;

关键词: multiple myeloma;    genomics;    gene expression profiling;   

DOI  :  10.3390/ijms19061721

来源: DOAJ

【 摘 要 】

Multiple myeloma is a heterogeneous disease with different characteristics, and genetic aberrations play important roles in this heterogeneity. Studies have shown that these genetic aberrations are crucial in prognostication and response assessment; recent efforts have focused on their possible therapeutic implications. Despite many emerging studies being published, the best way to incorporate these results into clinical practice remains unclear. In this review paper we describe the different genomic techniques available, including the latest advancements, and discuss the potential clinical application of genomics in multiple myeloma.

【 授权许可】

Unknown