The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications

International Journal of Molecular Sciences

Damian Mikulski¹  Paweł Robak²  Tadeusz Robak³  Anna Puła³ 

[1] Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland;Department of Experimental Hematology, Medical University of Lodz, 93-510 Lodz, Poland;Department of Hematology, Medical University of Lodz, 93-510 Lodz, Poland;

关键词: biology;    drug resistance;    gene expression profiling;    mRNA;    multiple myeloma;    prognosis;   

DOI  :  10.3390/ijms222112070

来源: DOAJ

【 摘 要 】

Multiple myeloma (MM) is a genetically complex disease that results from a multistep transformation of normal to malignant plasma cells in the bone marrow. However, the molecular mechanisms responsible for the initiation and heterogeneous evolution of MM remain largely unknown. A fundamental step needed to understand the oncogenesis of MM and its response to therapy is the identification of driver mutations. The introduction of gene expression profiling (GEP) in MM is an important step in elucidating the molecular heterogeneity of MM and its clinical relevance. Since some mutations in myeloma occur in non-coding regions, studies based on the analysis of mRNA provide more comprehensive information on the oncogenic pathways and mechanisms relevant to MM biology. In this review, we discuss the role of gene expression profiling in understanding the biology of multiple myeloma together with the clinical manifestation of the disease, as well as its impact on treatment decisions and future directions.

【 授权许可】

Unknown