Synthesis of functionalized spiro[indoline-3,4’-pyridines] and spiro[indoline-3,4’-pyridinones] via one-pot four-component reactions

Beilstein Journal of Organic Chemistry

Li-Juan Zhang¹  Chao-Guo Yan¹  Jing Sun¹  Qun Wu¹ 

[1] College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China;

关键词: 1,4-dihydropyridine;    electron-deficient alkyne;    four-component reaction;    isatin;    one-pot reaction;    spiro compound;   

DOI  :  10.3762/bjoc.9.97

来源: DOAJ

【 摘 要 】

In the presence of triethylamine as catalyst, the one-pot four-component reactions of arylamines, methyl propiolate, isatin and malononitrile afforded the functionalized spiro[indoline-3,4’-pyridine] derivatives in good yields. Similar reactions with ethyl cyanoacetate successfully afforded the functionalized spiro[indoline-3,4’-pyridines] and spiro[indoline-3,4’-pyridinones] as the main products according to the structures of the arylamines and other primary amines.

【 授权许可】

Unknown