Efficient, green and solvent-free synthesis of tetrasubstituted imidazoles using SbCl3/SiO2 as heterogeneous catalyst

Journal of Chemical Sciences

Javad Safari1¹  Simin Naseh¹  Soheila Gandomi-Ravandi¹ 

[1] Laboratory of Organic Chemistry Research, Department of Chemistry, College of Chemistry, University of Kashan, Kashan, P.O. Box: 87317 51167, Kashan, Iran$$

关键词: Imidazole;    solvent-free conditions;    four-component reaction;    heterogeneous catalyst;    Lewis acid.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Antimony trichloride absorbed on silica gel (SbCl3/SiO2) efficiently catalyses the four-component cyclocondensation of 1,2-diketone, aldehyde, ammonium acetate, and primary amine under solvent-free conditions to afford the corresponding tetrasubstituted imidazoles in high yields. The main merit of this study is introducing a novel catalyst to successful synthesis of a wide range of 1,2,4,5-tetrasubstituted imidazoles for the first time. The proposed method involves features such as simplicity, generality, fairly good efficiency, and reusability of the catalyst.

【 授权许可】

Unknown