Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis

Lipids in Health and Disease

Shou-Sheng Liu¹  Meng-Zhen Dong²  Jie Zhang²  Xue-Feng Ma²  Shui-Xian Du²  Jie Zhao³  Yong-Ning Xin⁴ 

[1] Central Laboratories, Qingdao Municipal Hospital, Qingdao University;Department of Infectious Disease, Qingdao Municipal Hospital, Qingdao University;Departments of Nephrology, Zibo Central Hospital;Digestive Disease Key Laboratory of Qingdao;

关键词: Nonalcoholic fatty liver disease;    Extrahepatic cancer;    Cholangiocarcinoma;    Colorectal cancer;    Breast cancer;    Gastric cancer;   

DOI  :  10.1186/s12944-020-01288-6

来源: DOAJ

【 摘 要 】

Abstract Background NAFLD is tightly associated with various diseases such as diabetes, cardiovascular disease, kidney disease, and cancer. Previous studies had investigated the association between NAFLD and various extrahepatic cancers, but the available data to date is not conclusive. The aim of this study was to investigate the association between NAFLD and various extrahepatic cancers comprehensively. Methods Searches were conducted of various electronic databases (PubMed, EMBASE, Medline, and the Cochrane Library) to identify observational studies published between 1996 and January 2020 which investigated the association between NAFLD and extrahepatic cancers. The pooled OR/HR/IRR of the association between NAFLD and various extrahepatic cancers were analyzed. Results A total of 26 studies were included to investigate the association between NAFLD and various extrahepatic cancers. As the results shown, the pooled OR values of the risk of colorectal cancer and adenomas in patients with NAFLD were 1.72 (95%CI: 1.40–2.11) and 1.37 (95%CI: 1.29–1.46), respectively. The pooled OR values of the risk of intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma in patients with NAFLD were 2.46 (95%CI: 1.77–3.44) and 2.24 (95%CI: 1.58–3.17), respectively. The pooled OR value of the risk of breast cancer in patients with NAFLD was 1.69 (95%CI: 1.44–1.99). In addition, NAFLD was also tightly associatied with the risk of gastric cancer, pancreatic cancer, prostate cancer, and esophageal cancer. Conclusions NAFLD could significantly increase the development risk of colorectal adenomas and cancer, intrahepatic and extrahepatic cholangiocarcinoma, breast, gastric, pancreatic, prostate, and esophageal cancer. NAFLD could be considered as one of the influencing factors during the clinical diagnosis and treatment for the extrahepatic cancers.

【 授权许可】

Unknown