Increased PD-L1 and p16 expression are common in oropharyngeal squamous cell carcinoma

Future Science OA

Tjoa Tjoson¹  Anna Shestakova²  Vishal Chandan³  Jeffrey Kim³  Ifegwu Ibe³  Jana Tarabay³  Anton Burtsev⁴  William B Armstrong⁵  Beverly Wang⁵ 

[1]Neck Surgery, University of California, Irvine, CA 92868, USA

[2]1Department of Pathology, University of Utah and ARUP laboratories, Salt Lake City, UT 84108, USA

[3]2Department of Pathology, University of California, Irvine, CA 92868, USA

[4]3Department of Computer Science, University of California, Irvine, CA 92697, USA

[5]

[6]4Department of Otolaryngology – Head &

关键词: hypopharynx;    larynx;    mouth;    oropharynx;    papillomaviridae;    pembrolizumab;   

DOI  :  10.2144/fsoa-2021-0039

来源: DOAJ

【 摘 要 】

Overexpression of p16 is closely related to human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (SCC) and pertains a prognostic relevance. Programmed cell death 1-ligand 1 (PD-L1) is another important marker, as anti-PD-L1 immunotherapy is available. Retrospective analysis of 57 cases of the SCC involving oropharynx (27 cases), hypopharynx (5 cases), larynx (11 cases), and oral cavity (14 cases) was performed. Each case was scrutinized for the basaloid morphology, p16, and PD-L1 expression. Basaloid morphology was identified in 47% of total cases. The majority of basaloid SCC variants were located in the oropharynx (89%). High expression of p16 was mostly observed in the oropharynx. High PD-L1 expression was seen predominantly in oropharyngeal and hypopharyngeal locations. Further studies in a larger cohort are necessary to correlate PD-L1 and p16 expression with survival.

【 授权许可】

Unknown