Clinic and epidemiologic characteristics in the with squamous cell carcinoma of the mouth and oropharynx

Revista Brasileira de Otorrinolaringologia

UNIFESP - Escola Paulista de Medicina¹  Complexo Hospitalar Heliópolis, São Paulo¹  Guimarães, Fernanda T.¹  Universidade Metropolitana de Santos (UNIMES)¹  Guimarães, André V.¹  Mafra, Ana Claudia B.¹  Dedivitis, Rogério A.¹  França, Cristiane M.¹  Universidade de São Paulo¹ 

关键词: squamous cell carcinoma;    oral cancer;    mouth;    oropharynx;    epidemiology.;   

DOI  :  10.1590/S0034-72992004000100006

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Cancer of the oral cavity and oropharynx is aggressive. It is one of the commonest cancers in Brazil and may be considered as the commonest in the head and neck.AIM: The objective of this paper is to evaluate clinical and epidemiological factors and the outcome.STUDY DESIGN: Clinical retrospective.MATERIAL AND METHODS: In a descriptive retrospective study, the charts of 43 cases of oral and 25 of oropharyngeal squamous cell carcinoma (SCC) in the period 1997-2000 have been reviewed from the Departments of Head and Neck Surgery of Santa Casa de Misericórdia de Santos and Hospital Ana Costa. This was analyzed with emphasis on age, gender, profession, ethnic aspects, tobacco and alcohol use, dental prosthesis, referement origin, site of the lesion, clinical staging, histologic grade, treatment methods, survival and second cancer presence in the study group. The data were analysed by Exact Test of Fischer.RESULTS: In the oral cavity cancer patients, a male female ratio of 3.35:1 was observed, the median age was 62 years (ranging 46 to 91 years), 90.7% were Caucasian, 81% were referred from medical professionals, tobacco use was identified in 76.8%, alcohol intake in 74%, 79% were not dental prosthesis users, tongue was the commonest site identified (51.1%), 53% were staged as III and IV clinical stages, 72.1% were moderately differentiated SCC, combined modality of treatment (surgery and adjuvant radiation therapy) was employed in 47% and 9.3% presented a second primary tumor. For the oropharynx, the male female ratio was 11.5:1, the median age was 58 years (ranging 40 to 81 years), 92% were Caucasian, 92% were referred from medical professionals, exposure to tobacco and alcohol was respectively noted in 84% and 80%, 52% did not use dental prosthesis, the tonsils were the commonest site (76%), 96% were staged as III and IV, 84% had moderately differentiated SCC, 75% underwent combined treatment (surgery and adjuvant radiation therapy) and 8% presented a second tumor elsewhere. There was not significant relationship between the clinical staging and tobacco, alcohol and dental prosthesis exposure. These factors, the age and the histologic grade had no relationship with the tumor site. For the oral cavity, 69,7% were alive with no evidence of disease and for the oropharynx, 22% were under this condition.CONCLUSION: The professional who performs the first evaluation is important in recognizing the lesions in order to achieve early detection.

【 授权许可】

Unknown