Characteristics of Carbapenemase-Producing Klebsiella pneumoniae Isolated in the Intensive Care Unit of the Largest Tertiary Hospital in Bangladesh

Frontiers in Microbiology

Qumrul Huda¹  Amirul Islam¹  Takashi Okanda²  Anwarul Haque²  Tetsuya Matsumoto²  Hiromu Takemura³  Takuro Koshikawa³  Shigeki Nakamura⁴ 

[1] Department of Anesthesia, Analgesia and Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh;Department of Infectious Diseases, International University of Health and Welfare, Narita, Japan;Department of Microbiology, St. Marianna University School of Medicine, Kawasaki, Japan;Department of Microbiology, Tokyo Medical University, Tokyo, Japan;

关键词: PDR;    ST147;    NDM-1;    NDM-5;    OXA-181;    OXA-232;   

DOI  :  10.3389/fmicb.2020.612020

来源: DOAJ

【 摘 要 】

For addressing the issue of antimicrobial drug resistance in developing countries, it is important to investigate the characteristics of carbapenemase-producing organisms. We aimed to genetically characterize a carbapenemase-producing Klebsiella pneumoniae (CPKP) isolated in the intensive care unit of a tertiary hospital in Bangladesh. The number of CPKP isolates were 43/145 (30%), of which pandrug-resistant (PDR) strains were 14%. These carbapenemases were New Delhi metallo-beta-lactamase (NDM)-1 (53%), NDM-5 (14%), oxacillinase (OXA)-181 (12%), OXA-232 (10%), NDM-5 + OXA-181 (5%), and NDM-5 + OXA-232 (2%). Many CPKP isolates harbored a variety of resistance genes, and the prevalence of 16S rRNA methyltransferase was particularly high (91%). The 43 CPKP isolates were classified into 14 different sequence types (STs), and the common STs were ST34 (26%), ST147 (16%), ST11 (9%), ST14 (9%), ST25 (7%), and ST231 (7%). In this study, PDR strains were of three types, ST147, ST231, and ST14, and their PDR rates were 57, 33, and 25%, respectively. The spread of the antimicrobial drug resistance of CPKP in Bangladesh was identified. In particular, the emergence of PDR is problem, and there may be its spread as a superbug of antimicrobial treatment.

【 授权许可】

Unknown