Patient management with diabetes mellitus in outpatient practice: prevention and treatment of vascular and neurological complications

Consilium Medicum

Tatiana E. Morozova¹  Natalia A. Konyshko¹ 

[1] I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;

关键词: diabetes mellitus;    microvascular complications;    diabetic microangiopathy;    diabetic neuropathy;    microvascular dysfunction;    dipyridamole;    thioctic acid;   

DOI  :  10.26442/20751753.2019.4.190325

来源: DOAJ

【 摘 要 】

Diabetes mellitus (DM) is an actual problem of modern medicine, which is determined, on the one hand, by its high prevalence, on the other, by a high risk of developing microvascular and macrovascular complications. Treatment of patients with DM should be comprehensive and include, along with individually selected glucose-lowering drugs, drugs that can influence the pathogenetic mechanisms of the development of microvascular complications. Microvascular dysfunction and neuropathy are key links in the pathogenesis of insulin resistance, b-cell dysfunction, hyperglycemia, clinical and laboratory manifestations, complications, and comorbid diabetes relationships. The use of drugs with antioxidant properties (dipyridamole, thioctic acid), having a pathogenetic effect and preventing the development of microvascular dysfunction in standard therapeutic doses is pathogenetically justified in patients with DM complicated by diabetic angiopathy and neuropathy.

【 授权许可】

Unknown