Role of ADMA in the pathogenesis of microvascular complications in type 2 diabetes mellitus

Frontiers in Endocrinology

Endocrinology

Xinyang Guo¹  Yiqiao Xing¹  Wei Jin¹ 

[1] Eye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, China;

关键词: diabetes mellitus;    asymmetric dimethylarginine;    microvascular complications;    diabetic retinopathy;    diabetic nephropathy;    diabetic neuropathy;    diabetic cardiomyopathy;   

DOI  :  10.3389/fendo.2023.1183586

 received in 2023-03-10, accepted in 2023-04-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

Diabetic microangiopathy is a typical and severe problem in diabetics, including diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, and diabetic cardiomyopathy. Patients with type 2 diabetes and diabetic microvascular complications have significantly elevated levels of Asymmetric dimethylarginine (ADMA), which is an endogenous inhibitor of nitric oxide synthase (NOS). ADMA facilitates the occurrence and progression of microvascular complications in type 2 diabetes through its effects on endothelial cell function, oxidative stress damage, inflammation, and fibrosis. This paper reviews the association between ADMA and microvascular complications of diabetes and elucidates the underlying mechanisms by which ADMA contributes to these complications. It provides a new idea and method for the prevention and treatment of microvascular complications in type 2 diabetes.

【 授权许可】

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Copyright © 2023 Guo, Xing and Jin