Nicotinic Acetylcholine Receptor α7 Subunit Is an Essential Regulator of Seizure Susceptibility

Frontiers in Neurology

Da-Gang Liu¹  Xiang-Ming Ye²  Peng Sun³ 

[1] Sports Medicine Research Institute of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China;Department of Neurosurgery Medicine, Weihai Central Hospital, Weihai, China;;Rehabilitation &

关键词: cholinergic receptors;    α7 nicotinic acetylcholine receptors;    epilepsy;    seizure susceptibility;    CA1 pyramidal neuron;   

DOI  :  10.3389/fneur.2021.656752

来源: DOAJ

【 摘 要 】

A large body of data has confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and other neuropsychiatric diseases, but their effect on seizure susceptibility in C57BL/6 wild-type mice is not fully understood. Here, we showed that decreased activity of α7 nAChRs could increase the excitability of CA1 pyramidal neurons and shorten the onset time of epilepsy in pilocarpine-induced mouse models. However, compared with the control group, there was no apparent effect of increasing the activity of α7 nAChRs. Moreover, the expression of α7 nAChRs is downregulated in human epileptogenic tissues. Taken together, our findings indicate that α7 nAChR is an essential regulator of seizure susceptibility.

【 授权许可】

Unknown