Mitochondrial Bioenergetics and Dynamism in the Failing Heart

Life

VeronicaAngela Maria Vitto¹  Carlotta Giorgi¹  Esmaa Bouhamida¹  Paolo Pinton²  Giampaolo Morciano² 

[1] Laboratory for Technologies of Advanced Therapies (LTTA), Section of Experimental Medicine, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy;Maria Cecilia Hospital, GVM Care&Research, 48033 Cotignola, Italy;

关键词: mitochondria;    heart failure;    bioenergetics;    mitochondrial dynamics;   

DOI  :  10.3390/life11050436

来源: DOAJ

【 摘 要 】

The heart is responsible for pumping blood, nutrients, and oxygen from its cavities to the whole body through rhythmic and vigorous contractions. Heart function relies on a delicate balance between continuous energy consumption and generation that changes from birth to adulthood and depends on a very efficient oxidative metabolism and the ability to adapt to different conditions. In recent years, mitochondrial dysfunctions were recognized as the hallmark of the onset and development of manifold heart diseases (HDs), including heart failure (HF). HF is a severe condition for which there is currently no cure. In this condition, the failing heart is characterized by a disequilibrium in mitochondrial bioenergetics, which compromises the basal functions and includes the loss of oxygen and substrate availability, an altered metabolism, and inefficient energy production and utilization. This review concisely summarizes the bioenergetics and some other mitochondrial features in the heart with a focus on the features that become impaired in the failing heart.

【 授权许可】

Unknown