Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin

Marine Drugs

Adnan Badwan¹  Deeb Abu Fara²  Linda Al-Hmoud²  Iyad Rashid³  BaburZ. Chowdhry⁴ 

[1] Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK;Chemical Engineering Department, School of Engineering, University of Jordan, Amman 11942, Jordan;Research and Innovation Centre, The Jordanian Pharmaceutical Manufacturing Company (JPM), P.O. Box 94, Naor 11710, Jordan;;School of Science, Faculty of Engineering &

关键词: chitin;    roller compaction;    ball milling;    direct compression;    compression work;    crushing strength;    hausner ratio;    kawakita analysis;    bulk density;    dissolution;   

DOI  :  10.3390/md18020115

来源: DOAJ

【 摘 要 】

Chitin has been investigated in the context of finding new excipients suitable for direct compression, when subjected to roller compaction. Ball milling was concurrently carried out to compare effects from different energy or stress-inducing techniques. Samples of chitin powders (raw, processed, dried and humidified) were compared for variations in morphology, X-ray diffraction patterns, densities, FT-IR, flowability, compressibility and compactibility. Results confirmed the suitability of roller compaction to convert the fluffy powder of raw chitin to a bulky material with improved flow. X-ray powder diffraction studies showed that, in contrast to the high decrease in crystallinity upon ball milling, roller compaction manifested a slight deformation in the crystal lattice. Moreover, the new excipient showed high resistance to compression, due to the high compactibility of the granules formed. This was correlated to the significant extent of plastic deformation compared to the raw and ball milled forms of chitin. On the other hand, drying and humidification of raw and processed materials presented no added value to the compressibility and compactibility of the directly compressed excipient. Finally, compacted chitin showed direct compression similarity with microcrystalline cellulose when formulated with metronidazole (200 mg) without affecting the immediate drug release action of the drug.

【 授权许可】

Unknown