Tumor-Associated Microbiota in Esophageal Squamous Cell Carcinoma

Frontiers in Cell and Developmental Biology

Lu Gao¹  Chang-Han Chen²  Hsin-Ting Tsai²  Minghan Jia³  Sai-Ching Jim Yeung⁴  Xiangbin Xing⁵  Zhanfei Zhang⁶  Zhenguo Liu⁶  Bo Zeng⁶  Chao Cheng⁶  Weixiong Yang⁶  Mong-Hong Lee⁷ 

[1] BGI Genomics, BGI-Shenzhen, Shenzhen, China;Department of Applied Chemistry, and Graduate Institute of Biomedicine and Biomedical Technology, National Chi Nan University, Nantou County, Taiwan;Department of Breast Cancer, Cancer Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China;Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States;Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;Department of Thoracic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;Guangdong Research Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;

关键词: esophageal squamous cell carcinoma;    microbiota;    microbial dysbiosis index;    carcinogenesis;    Fusobacteria;   

DOI  :  10.3389/fcell.2021.641270

来源: DOAJ

【 摘 要 】

Important evidence indicates the microbiota plays a key role in esophageal squamous cell carcinoma (ESCC). The esophageal microbiota was prospectively investigated in 18 patients with ESCC and 11 patients with physiological normal (PN) esophagus by 16S rRNA gene profiling, using next-generation sequencing. The microbiota composition in tumor tissues of ESCC patients were significantly different from that of patients with PN tissues. The ESCC microbiota was characterized by reduced microbial diversity, by decreased abundance of Bacteroidetes, Fusobacteria, and Spirochaetes. Employing these taxa into a microbial dysbiosis index demonstrated that dysbiosis microbiota had good capacity to discriminate between ESCC and PN esophagus. Functional analysis characterized that ESCC microbiota had altered nitrate reductase and nitrite reductase functions compared with PN group. These results suggest that specific microbes and the microbiota may drive or mitigate ESCC carcinogenesis, and this study will facilitate assigning causal roles in ESCC development to certain microbes and microbiota.

【 授权许可】

Unknown