Point-of-Care Testing for G6PD Deficiency: Opportunities for Screening

International Journal of Neonatal Screening

AriW. Satyagraha¹  GonzaloJ. Domingo²  Sampa Pal²  Emily Gerth-Guyette²  Athena Anderle²  Germana Bancone³ 

[1] Eijkman Institute, Jalan Diponegoro 69, Jakarta 10430, Indonesia;PATH, 2201 Westlake Ave, Suite 200, Seattle, WA 98121, USA;Shoklo Malaria Research Unit, Mahidol–Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 68/30 Bantung Road, PO Box 46 Mae Sot, Tak 63110, Thailand;

关键词: glucose-6-phosphate dehydrogenase;    G6PD deficiency;    point-of-care;    diagnostics;    malaria;    Plasmodium vivax;   

DOI  :  10.3390/ijns4040034

来源: DOAJ

【 摘 要 】

Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked genetic disorder, is associated with increased risk of jaundice and kernicterus at birth. G6PD deficiency can manifest later in life as severe hemolysis, when the individual is exposed to oxidative agents that range from foods such as fava beans, to diseases such as typhoid, to medications such as dapsone, to the curative drugs for Plasmodium (P.) vivax malaria, primaquine and tafenoquine. While routine testing at birth for G6PD deficiency is recommended by the World Health Organization for populations with greater than 5% prevalence of G6PD deficiency and to inform P. vivax case management using primaquine, testing coverage is extremely low. Test coverage is low due to the need to prioritize newborn interventions and the complexity of currently available G6PD tests, especially those used to inform malaria case management. More affordable, accurate, point-of-care (POC) tests for G6PD deficiency are emerging that create an opportunity to extend testing to populations that do not have access to high throughput screening services. Some of these tests are quantitative, which provides an opportunity to address the gender disparity created by the currently available POC qualitative tests that misclassify females with intermediate G6PD activity as normal. In populations where the epidemiology for G6PD deficiency and P. vivax overlap, screening for G6PD deficiency at birth to inform care of the newborn can also be used to inform malaria case management over their lifetime.

【 授权许可】

Unknown