The Role of Astrocytes in Multiple Sclerosis

Frontiers in Immunology

David Pitt¹  Gerald Ponath¹  Calvin Park¹ 

[1] Department of Neurology, Yale School of Medicine, New Haven, CT, United States;

关键词: astrocytes;    multiple sclerosis;    neuroinflammation;    NF-κB;    risk variant;    leukocyte recruitment;   

DOI  :  10.3389/fimmu.2018.00217

来源: DOAJ

【 摘 要 】

The role traditionally assigned to astrocytes in the pathogenesis of multiple sclerosis (MS) lesions has been the formation of the glial scar once inflammation has subsided. Astrocytes are now recognized to be early and highly active players during lesion formation and key for providing peripheral immune cells access to the central nervous system. Here, we review the role of astrocytes in the formation and evolution of MS lesions, including the recently described functional polarization of astrocytes, discuss prototypical pathways for astrocyte activation, and summarize mechanisms by which MS treatments affect astrocyte function.

【 授权许可】

Unknown