RelB and Neuroinflammation

Cells

Alexandra Gonsiewski¹  Tomasz Kordula¹  Karli Mockenhaupt¹ 

[1]Department of Biochemistry and Molecular Biology, School of Medicine and the Massey Cancer Center, Virginia Commonwealth University, Richmond, VI 23298, USA

关键词: neuroinflammation;    NF-κB;    RelB;    astrocytes;    microglia;    oligodendrocytes;   

DOI  :  10.3390/cells10071609

来源: DOAJ

【 摘 要 】

Neuroinflammation within the central nervous system involves multiple cell types that coordinate their responses by secreting and responding to a plethora of inflammatory mediators. These factors activate multiple signaling cascades to orchestrate initial inflammatory response and subsequent resolution. Activation of NF-κB pathways in several cell types is critical during neuroinflammation. In contrast to the well-studied role of p65 NF-κB during neuroinflammation, the mechanisms of RelB activation in specific cell types and its roles during neuroinflammatory response are less understood. In this review, we summarize the mechanisms of RelB activation in specific cell types of the CNS and the specialized effects this transcription factor exerts during neuroinflammation.

【 授权许可】

Unknown