Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer

Biomolecules

Soha Mcheik¹  Véronique D’Hondt¹  Peter Coopman¹  Leticia Aptecar¹  Gilles Freiss¹ 

[1] IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut Régional du Cancer de Montpellier, F-34298 Montpellier, France;

关键词: PTPN13;    cell signaling;    cancer;    tumor suppressor;    oncogene;   

DOI  :  10.3390/biom10121659

来源: DOAJ

【 摘 要 】

In this review article, we present the current knowledge on PTPN13, a class I non-receptor protein tyrosine phosphatase identified in 1994. We focus particularly on its role in cancer, where PTPN13 acts as an oncogenic protein and also a tumor suppressor. To try to understand these apparent contradictory functions, we discuss PTPN13 implication in the FAS and oncogenic tyrosine kinase signaling pathways and in the associated biological activities, as well as its post-transcriptional and epigenetic regulation. Then, we describe PTPN13 clinical significance as a prognostic marker in different cancer types and its impact on anti-cancer treatment sensitivity. Finally, we present future research axes following recent findings on its role in cell junction regulation that implicate PTPN13 in cell death and cell migration, two major hallmarks of tumor formation and progression.

【 授权许可】

Unknown