BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease

International Journal of Molecular Sciences

Atsuko Nakanishi¹  Akari Minami²  Yasuko Kitagishi²  Yasunori Ogura²  Satoru Matsuda¹ 

[1] Department of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, Japan;

关键词: BRCA1;    p53;    Alzheimer’s disease;    tumor suppressor;    DNA repair;    cell signaling;    dietary supplementation;   

DOI  :  10.3390/ijms16022879

来源: mdpi

【 摘 要 】

Tumor suppressor molecules play a pivotal role in regulating DNA repair, cell proliferation, and cell death, which are also important processes in the pathogenesis of Alzheimer’s disease. Alzheimer’s disease is the most common neurodegenerative disorder, however, the precise molecular events that control the death of neuronal cells are unclear. Recently, a fundamental role for tumor suppressor molecules in regulating neurons in Alzheimer’s disease was highlighted. Generally, onset of neurodegenerative diseases including Alzheimer’s disease may be delayed with use of dietary neuro-protective agents against oxidative stresses. Studies suggest that dietary antioxidants are also beneficial for brain health in reducing disease-risk and in slowing down disease-progression. We summarize research advances in dietary regulation for the treatment of Alzheimer’s disease with a focus on its modulatory roles in BRCA1 and p53 tumor suppressor expression, in support of further therapeutic research in this field.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.