Antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera

Bangladesh Journal of Pharmacology

Rachida Aboufatima¹  Majda Badaoui²  Abderrahman Chait²  Soad Moubtakir²  Chafik Terrafe² 

[1] Laboratory of Genie Biologic, Sultan Moulay Slimane University, Faculty of Sciences and Technics, Beni Mellal, Moroocco.;Laboratory of Pharmacology, Neurobiology, Anthropology and Environment, Department of Biology, Faculty of Sciences, Semlalia, University Cadi Ayyad, BP 2390-40080 Marrakech, Morocco.;

关键词: Antidepressant;    Anxiolytic;    Antioxidant;    Elevated plus maze test;    Euphorbia re;   

DOI  :  10.3329/bjp.v17i2.59258

来源: DOAJ

【 摘 要 】

This study aims to examine the antianxiety and antidepressant effects of aqueous latex extract of Euphorbia resinifera in mice. Antianxiety and sedative effects were examined using the elevated plus maze test, open field test, and thiopental-induced sleeping time respectively. While the antidepressant effect was evaluated, using the forced swimming test. E. resinifera reduced the latency of sleeping and increased sleeping time significantly at 75 mg/kg. It reduced the immobility time and increased swimming significantly at all doses assessed (25, 50, and 75 mg/kg). Pretreatment with antagonists reversed these effects indicating the possible involvement of α2, 5HT2, D2, and GABAA receptors respectively. These findings confirm the traditional utilization of this plant as an antioxidant, anxiolytic, and antidepressant.

【 授权许可】

Unknown