Comparative central effects of the aqueous leaf extract of two populations of Passiflora edulis

Revista Brasileira de Farmacognosia

Soares-Rachetti, Vanessa P.¹  Ramos, Freddy A.¹  Zucolotto, Silvana M.¹  Schenkel, Eloir P.¹  Castellanos, Leonardo¹  Soares, Thaciane C.¹  Universidade Federal de Santa Catarina, Florianópolis, Brazil¹  Reginatto, Flávio H.¹  Ayres, Adriana S.F.S.J.¹  Universidad Nacional de Colombia, Bogotá, Colombia¹  Universidade Federal do Rio Grande do Norte, Natal, Brazil¹  Costa, Geison M.¹  Gavioli, Elaine C.¹  Araújo, Luana L.S. de¹ 

关键词:   Passiflora edulis edulis;    Passiflora edulis flavicarpa;    Anxiolytic;    Antidepressant;    Sedation;    Animal models;   

DOI  :  10.1016/j.bjp.2015.06.007

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Passiflora edulis Sims, Passifloraceae, has been used in Brazilian traditional folk medicine to the treatment of anxiety and insomnia. P. edulis is commonly known for its economic interests in Brazil. This species exhibits significant variability in the fruit rind color, then two subpopulations has been described (P. edulis fo. flavicarpa O. Deg. (PEF); P. edulis fo. edulis (PEE)). This study compared phytochemical profile and biological actions of aqueous leaf extract of PEE and PEF. HPLC analysis showed marked distinct chromatograms to the P. edulisvarieties. However, in both extracts the major compounds observed were flavonoids C-glycosides. Behavioral studies showed that PEE (300 mg/kg, p.o.) and PEF (100 and 300 mg/kg, p.o.) reduced anxiety in the elevated plus maze test. PEE (300 and 1000 mg/kg, p.o.) and PEF (1000 mg/kg, p.o.) also induced antidepressant-like actions in the forced swimming test. PEE 1000 mg/kg significantly reduced distance moved, thus suggesting sedation. No alterations in sleeping time were observed with PEE and PEF extracts. In conclusion, despite the similarities between the biological actions observed for both P. edulis varieties, quite different phytochemical profile was herein reported. These data suggest that the anxiolytic and antidepressant actions are not due to a specific phytochemical component.

【 授权许可】

Unknown