Bulky-Yet-Flexible Carbene Ligands and Their Use in Palladium Cross-Coupling

Inorganics

CatherineS. J. Cazin¹  SofieM. P. Vanden Broeck¹  Fady Nahra¹ 

[1] Centre for Sustainable Chemistry, Department of Chemistry, Ghent University, Krijgslaan 281-S3, B-9000 Gent, Belgium;

关键词: N-heterocyclic carbenes;    flexible sterics;    palladium;    cross-coupling;   

DOI  :  10.3390/inorganics7060078

来源: DOAJ

【 摘 要 】

In recent years, several classes of new N-heterocyclic carbene (NHC) ligands were developed around the concept of “flexible steric bulk”. The steric hindrance of these ligands brings stability to the active species, while ligand flexibility still allows for the approach of the substrate. In this review, the synthesis of several types of new classes, such as IBiox, cyclic alkyl amino carbenes (CAAC), ITent, and IPr* are discussed, as well as how they move the state-of-the-art in palladium catalyzed cross-coupling forward.

【 授权许可】

Unknown